However, interestingly, similar to the role of R848 in pancreatic cancer (27), the percentage of dendritic cells (DCs, CD11B+MHCII+CD11C+F4/80-) as a percent of CD45+ cells in both the R848 group and the RFA+R848 group was significantly reduced, while there was no difference in the proportion of CD86+ DCs to the total DCs between groups (Supplementary Figures S4F, G). This evidence concerns the gene ITGAX and familial pancreatic carcinoma.