Various demographic and clinical variables were reported that show inferior prognosis for LUAD with bone metastasis to include: male gender (21), smoking history (20), cachexia (7), malnutrition (7), poor physical status (21, 26), multiple and/or wearing bone metastases (4, 7, 26), KRAS mutation (7, 22), and without targeted therapy mutations (6, 8). The gene discussed is KRAS; the disease is Cachexia.