ANGPTL4 was induced by TGF-β through Smad signal transduction pathway (71, 72), which resisted the tight connection and adherent connection of vascular endothelia, destroyed the integrity of capillary wall, increased the permeability of pulmonary capillary, as well as induced tumor cells to exudate from blood vessels and entered the lung tissues for colonization and growth (66, 67). The gene discussed is TGFB1; the disease is neoplasm.