Using whole-exome sequencing (WES) data from the Tumor Cancer Genome Atlas (TCGA), we found that PBRM1-mutant ccRCC had a significantly higher TMB than PBRM1-WT tumors (**, P < 0.01, Mann–Whitney U test, Figure S6A). The gene discussed is PBRM1; the disease is nonpapillary renal cell carcinoma.