The results demonstrated that 33 genes (ADM, ATP2B1, CCL20, EREG, GNAI3, IRAK2, MMP14, NAMPT, NMI, PCDH7, PLAUR, PVR, RELA, RIPK2, SERPINE1, SPHK1, TAPBP, TPBG, BTG2, CD48, CD69, CXCR6, CYBB, IL7R, IL12B, MEP1A, NMUR1, PDE4B, SLAMF1, SLC1A2, SLC11A2, and STAB1) were significantly related to the prognosis of lung cancer patients. Here, CXCR6 is linked to lung cancer.