Table 4 shows that the DNMT1 level in cancer cells and their stromal fibroblasts is a strong independent predictor of OS (P = 0.011) and (P = 0.0360), respectively. Furthermore, DNMT1 level in fibroblasts was also an independent prognostic factor for DFS (P = 0.0492) (Table 4). The gene discussed is DNMT1; the disease is cancer.