CDH1 and cancer: Anyway, it has been postulated that more aggressive clinicopathological as well as morphological findings of mixed-type cancers (10, 31) could be attributed to the angiogenetic process and cell proliferation, to cytosine-phosphate-guanine (CpG) island hypermethylation (32), or to the unregulated expression of proteins such as Ki-67, E-cadherin, and VEGF proteins, which were involved in proliferation (10), adhesion, and angiogenesis activities (10, 28).