The restoration of its expression in pre-B ALL could have potential therapeutic implications as has been reported for other downregulated lincRNAs in ALL, including RP11-446E9 and linc-PINT, in which their induced expression promotes tumor suppressor phenotypes and reduces cell proliferation and migration in ALL cell lines (49, 50). The gene discussed is LINC-PINT; the disease is acute lymphoblastic leukemia.