SYDE1 and cancer: By knocking down LINC00173 in human CD34+ hematopoietic stem and progenitor cells, it was demonstrated that this lincRNA modifies the methylation patterns at the promoter regions of a set of stem cell genes, which include HOXA7, HOXA9, HOXA10, and SYDE1. All these genes are involved in hematopoiesis and cancer (45–48).