KRAS and colorectal carcinoma: We next explored the effect of fibroblast-CM in modulating functional response to Geda in four PTEN-competent CRC cell lines (LS180, HT29, RKO, and SW480), characterized by different genetic background (KRAS-mut/PIK3CA-mut, KRAS-wt/PIK3CA-wt, KRAS-wt/PIK3CA-mut, and KRAS-mut/PIK3CA-wt, respectively) (Figures 2A, B).