PIK3CA and colorectal carcinoma: While the epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) pathways have been successfully targeted for therapeutic purposes in advanced CRC, the prognostic and therapeutic role of other crucial signaling cascades frequently altered in CRC, such as the phosphatidylinositol 3-kinase (PI3K) pathway, remain elusive (2).