Conversely, exposure to fibroblast-CM specifically sensitized PTEN-competent (HCT116 Parental), but not PTEN-loss (HCT116 PTEN-/-) CRC cells to Geda [48% reduction in the IC50 in HCT116 Parental cells under CM HFF, as compared with wo FBS, conditions (Table 1), p-value <0.05 at all the tested doses (Figure 1A left panels)]; direct co-co had no effect on sensitivity to Geda, regardless of PTEN status (Figure 1A right panels and Table 1). The gene discussed is PTEN; the disease is colorectal carcinoma.