Shin et al. demonstrated that the active PLK1 (p-Thr210 PLK1) is abundant in TGFβ-induced metastatic NSCLC and its presence promoted in vivo metastasis formation; active PLK1 led to an increase of the levels of TGFβ cascade effectors, including SNAI1, SNAI2, ZEB1, CDH2, IL11, and TNFAIP6, whose depletion resulted in a reversion of the EMT induced by active PLK1 (73). The gene discussed is PLK1; the disease is non-small cell lung carcinoma.