STAT3 and neoplasm: In JAK/STAT pathway, STAT1 is known to involve in anti-tumor immunity, while STAT3 is found to act as a transcriptional activator through binding to the promoter of LIV-1 genes in a tyrosine phosphorylation-dependent manner, resulting in the overexpression of LIV-1, which can stabilize Snail by inactivating of GSK3β, leading to EMT progress (44).