In the past few decades, besides the multi-faceted consideration of EMT-related invasiveness, the switch of cell surface markers from E-cadherin to N-cadherin and vimentin has been increasingly used to monitor the EMT process during cancer development as the hallmarks (22).The process of EMT contains the decomposition of epithelial cell-cell contacts, the loss of cell polarity, and the acquisition of mesenchymal features (Figure 1). This evidence concerns the gene CDH2 and cancer.