BRG1 is essential for melanoma cell proliferation in vitro and for normal melanocyte development in vivo and combinations of MITF, SOX10, TFAP2A, and YY1 bind between two BRG1-occupied nucleosomes thus defining both a signature of transcription factors essential for the melanocyte lineage and a specific chromatin organization of the regulatory elements they occupy (71). Here, SMARCA4 is linked to melanoma.