GSEA revealed the top five active pathways in the high-risk group including cell cycle, endometrial cancer, ERBB signaling pathway, TGF-β signaling pathway, and WNT signaling pathway (Figure 7A), while the low-risk group included allograft rejection, autoimmune thyroid disease, graft versus host disease, intestinal immune network for IgA production, and primary immunodeficiency (Figure 7B). This evidence concerns the gene TGFB1 and autoimmune thyroid disease.