IR, overproduction of very-low-density lipoprotein (VLDL), aberrant lipoprotein lipase-mediated lipolysis, and a malfunction in the insulin-signaling pathway mediated by overexpression of the PI3KR1 gene are among the mechanisms through which increased adiposity occurs, which in turn links dyslipidemia to PCOS. Here, INS is linked to polycystic ovary syndrome.