YAP1 and cancer: As with LMNA, the YAP1 gene does not show binding sites for FOXM1 based on the ChIP-seq signal, which again argues against direct cell cycle regulation of YAP1. In the pan-cancer analysis of TCGA data (Vashisth et al., 2021), tumors had both higher and lower levels of YAP1 relative to adjacent normal tissue, and the variation proved similar to other mechanosensitive genes especially LMNA. Such results concur with the similarities of expression patterns across normal tissues for YAP1 and LMNA [Figs. 2(a) and 2(b)].