In similar studies of solid tissue stem cells and tumor cells, overexpression of lamin-A,C impeded migration or immobilizes cells (Harada et al., 2014), which would tend to favor tissue solidity, and in strong confinement, a transition to ameboid migration is likewise inhibited by high levels of lamin-A (Lavenus et al., 2022). The gene discussed is LMNA; the disease is neoplasm.