IGFBP2 and Intellectual disability: SNP-array technology revealed that I-2, II-2, and II-3 harbored an approximately 4.4 Mb heterozygous duplication in 15q11.2-q13.1 (Figure 3E), and analysis of fetal amniotic fluid cells (III-1) indicated that the fetus carried the same CNV 15q11.2q13 recurrent (PWS/AS) region (Class 1, BP1-BP3) and 15q11.2q13 recurrent (PWS/AS) region (Class 2,BP2-BP3) in the fragment have sufficient evidence for triplosensitivity, associated with autism, intellectual disability, seizures, and psychiatric disorders (Christian et al., 2008; Ingason et al., 2011).