Additionally her first son suffered from retarded intellectual and language development that had not been detected (II-1) 16p13.11 recurrent region (BP2-BP3) (includes MYH11) in the fragment has sufficient evidence for haploinsufficiency, associated with intellectual disability and/or multiple congenital anomalies (de Kovel et al., 2010; Jähn et al., 2013). The gene discussed is IGFBP2; the disease is Intellectual disability.