Accordingly, we hypothesized that genetic polymorphisms rs2472493 located upstream of the ABCA1 gene and rs7636836 in FNDC3B were previously reported to be associated with POAG and elevated IOP (Hysi et al., 2014; Shiga et al., 2018), may also be associated with PACG and PXG in Saudi patients. The gene discussed is FNDC3B; the disease is open-angle glaucoma.