FNDC3B codes for an extracellular matrix protein that has a vital role in cell adhesion and growth signaling pathways, including TGFβ, and Wnt/β-catenin signaling (Nishizuka et al., 2009; Goto et al., 2017; Li et al., 2020) all of which have been strongly implicated in glaucoma pathogenesis (Prendes et al., 2013; Zhong et al., 2013; Webber et al., 2018). Here, FNDC3B is linked to glaucoma.