DO analysis revealed that DEGs PSAT1, FOLR1, ABCB1, SFRP1, SFRP1, BUB1B have a greater association with female reproductive system tumor-related diseases, such as malignant ovarian surface epithelial-mesenchymal tumor, ovarian epithelial carcinoma, and ovarian cancer. The gene discussed is BUB1B; the disease is ovarian cancer.