SFRP2 and gallbladder cancer: (Zheng et al., 2021) Interestingly, another study on gallbladder cancer found that HuR protein specifically binds with lncRNAs-HGBC within the 1759–1906 nt-long region and enhances the stabilization of lncRNAs-HGBC (Hu et al., 2019) Moreover, the lncRNA AK137033 was found to interact with mRNA Sfrp2 and HuR, forming the AK137033-Sfrp2-HuR complex, which contributes to the inhibition of cardiac fibrosis.