HNSCC, which mainly affects the oral cavity, pharynx, and larynx, is among one the ten malignancies with more than 600,000 new cases worldwide annually (Siegel et al., 2017; Xu et al., 2020) The notable upregulation of LINC00467 in HNSCC promotes cell growth, cell migration, and EMT by sponging miR-299-5p, thereby upregulating the expression of the oncogene tumor ubiquitin specific protease-48 (USP48), ultimately leading to HNSCC progression. The gene discussed is USP48; the disease is head and neck squamous cell carcinoma.