Zhang et al. reported that the circulating exosome lncRNA DLX6-AS1 expression levels in the serum of patients with NSCLC were significantly higher than those in healthy donors, and its specificity and sensitivity were higher than that of CYFRA21-1 (Ding et al., 2021), which served as a diagnostic marker in NSCLC. The gene discussed is DLX6; the disease is non-small cell lung carcinoma.