DLX6 and diabetic kidney disease: Tan et al. (2020) reported that the knockout of lncRNA DLX6-AS1 regulated the miR-223-3p/NLRP3 axis in HK-2 cells to induce sepsis-induced acute kidney injury. In addition, Zheng et al. (2022) first demonstrated that over-expressed cAMP-response element binding protein (CREB) induces podocyte injury in diabetic nephropathy via upregulating the lncRNA DLX6-AS1 expression level in vitro and in vivo.