CHD8 and autism spectrum disorder: Mariani et al. (2015) revealed that lncRNA DLX6-AS1 was one of the top ten up-regulated genes in cerebral organoids derived from members of a family with idiopathic ASD at TD11 and TD31. Wang et al. (2017) also found that DLX6-AS1 and DLX1 were two of three DEGs in CHD8+/- (CHD8 is a highly mutated gene in autism spectrum disorders) cerebral organoids, which increased ∼39- and 13-fold, respectively, and were hardly expressed in controls (Wang et al., 2017).