SRPK2 and cancer: Furthermore, despite the vital role of O-GlcNAcylation in inducing nuclear translocation of SRPK2, thus promoting posttranscriptional de novo lipogenesis and cancer cell growth, in about 50% of MCF-7 cells no staining of SRPK2 was detected in the nucleus, while in the remaining 50%, SRPK2 was mainly cytoplasmic, suggesting that only a fraction of the kinase was O-GlcNAcylated and imported to the nucleus (Tan et al., 2021).