MCM4 and neoplasm: In recent years, the effect of MCM4 on tumors has been widely revealed, and it is highly expressed in tumor tissues of gastric, colorectal, breast and liver, and is associated with poor prognosis (Ahluwalia et al., 2019; Guo et al., 2020; Wang N et al., 2021; Zhou et al., 2021), which can be used as a reliable prognostic marker.