Additionally, McConechy et al., (2016) reported that the POLE and MSI molecular subtypes of endometrial cancer, typical of the high mutational load subtypes, produce a large number of tumor-specific neoantigens and tumor-infiltrating lymphocytes that participate in the active immune microenvironment, leading to overexpression of PD-1 and PD-L1. The gene discussed is CD274; the disease is endometrial cancer.