SLC9A3 and inflammatory bowel disease: Despite not seeing significant differences at the phylum level for the abundance of Bacteroidetes and Firmicutes in our study with inducible intestinal epithelial cell-specific NHE3 deletion, we did find that the Firmicutes : Bacteroidetes (F:B) ratio tended to be lower in NHE3IEC-KO compared with control mice, which is consistent with previous studies demonstrating that a reduced F:B ratio favors IBD progression (Stojanov et al., 2020).