Moreover, miR-223 has immune modulatory functions and has been shown to be involved in a variety of immune modulated diseases by the regulation of the NFκB pathway or the NLRP3 inflammasome, making this miRNA an interesting target for further investigation in CHB (Valmiki et al., 2019; Xu et al., 2020). Here, NLRP3 is linked to glycogen storage disease VI.