In addition, treatment of homozygous mice bearing 4T1 TNBC tumors with G47Δ-mIL12 was able to reduce MDSCs, leading to CD8 T cell-dependent inhibition of 4T1 tumor growth, inhibition of tumor angiogenesis, and prevention of lung metastasis, while increasing intra-tumor CD8 T cell infiltration, with local and systemic anti-cancer effects (Ghouse et al., 2020). Here, CD8A is linked to cancer.