Propranolol was discovered to improve the anti-tumor efficacy of viral T1012G in gastric cancer cells by modulating STAT3-PKR-dependent anti-viral responses, which were maintained with type I IFN application, and that β-adrenergic receptor inhibition may provide optimal survival conditions for oncolytic viruses by enhancing intracellular viral replication (Hu et al., 2021b). The gene discussed is STAT3; the disease is neoplasm.