Phosphorylated proteome is involved in smooth muscle tumor growth, and biomimetic analysis revealed ten tumorigenic signaling pathways (FAS signaling pathway, p38 MAPK pathway, VEGF signaling pathway, Rho GTPase regulation of cytoskeleton, integrin signaling pathway, apoptosis signaling pathway, angiogenesis, gonadotropin-releasing hormone receptor pathway, ubiquitin-proteasome pathway, chemokines, and cytokine-mediated inflammatory signaling pathways) and four phosphoproteins (HSPA5, HSPB1, HSPD1, and PDRX2) involved in apoptosis and inhibition of cell survival [42]. Here, HSPA5 is linked to smooth muscle tumor.