AKT1 and cocaine dependence: The miR-149-3p target genes are involved in PI3K-Akt signaling pathway, Ras signaling pathway, AGE-RAGE signaling pathway in diabetic complications, focal adhesion, MAPK signaling pathway, proteoglycans in cancer, hypertrophic cardiomyopathy, cholinergic synapse, cocaine addiction, and protein digestion and absorption (Figure 8).