Regarding Figure 4B, bioactive compounds from BOSB not only participates in atherosclerosis pathways, but these are also involved in the hepatic immune and inflammatory response, obstructing NF-κB translocation into the nucleus and avoiding the production of classical pro-inflammatory cytokines such as TNF-α, IL11, the colony stimulating factor (CSF), and the Macrophage-derived Oncostatin M (OSM). The gene discussed is TNF; the disease is atherosclerosis.