SEMG2 and Infertility: After western blotting was performed, ANXA2 (annexin A2) and CDC42 (cell division control protein 42 homolog) were found to be overexpressed, while SEMG2 (semenogelin-2) underexpressed in primary infertility, and proteins ANXA2 (annexin A2) and APP (amyloid precursor protein) were overexpressed in secondary infertility and could potentially serve as biomarkers in the identification of infertility [43].