They modulate cancer cell survival via the mitochondria and ER ‐stimulated apoptosis mechanisms and by the downregulation of cancer cell survival pathways including NF‐kB, MAPK, Wnt, and phosphatidylinositol‐3‐kinase/protein kinase B (PI3K/AKT) immune regulators (Figure 6).137, 138. Here, NFKB1 is linked to cancer.