PARP1 and Familial prostate cancer: In comparison, gamma‐tocotrienol also possesses the capability for inducing autophagy as shown in breast cancer and prostate cancer cells in which it stimulated an increased Beclin‐2 and Bax/Bcl‐2 ratio, cleaved caspase 3, cleaved PARP, and diminished signaling of PI3K/AKT/mTOR activation that adds to anticancer properties of tocotrienol in inducing apoptosis and autophagy leading to tumor cell death (Figure 10).144, 145