HK2 and hepatocellular carcinoma: Additional multivariate regression analysis found that high expression of HK2 (HR = 1.893, 95% CI: 1.164–3.079), age ≥ 61 years (HR = 1.026, 95% CI: 1.005–1.047), and distant metastasis (HR = 2.298, 95% CI: 1.253–4.215) were independent predictors of increased mortality in HCC patients (Table 2).