Finally, AS3MT has also been highlighted in a GWAS of Alzheimer's disease (Demichele‐sweet et al., 2018), a methylome‐wide association study (MWAS) of Alzheimer's disease and psychosis (Pishva et al., 2020), and is differentially expressed in patients with depression (Li et al., 2016). This evidence concerns the gene AS3MT and early-onset autosomal dominant Alzheimer disease.