Second, tumor cells were capable of endogenous production of fibrinogen, and that fibrinogen could bind to some growth factors, such as vascular endothelial growth factor and fibroblast growth factor, and facilitate these growth factors binding to their receptors on the tumor cell surface, which plays a crucial role in contributing to tumor proliferation and angiogenesis.34, 35. The gene discussed is VEGFA; the disease is neoplasm.