METTL3 and Alzheimer disease: In addition, a recent study examining the expression profiles of m6A‐regulated genes in human AD post‐mortem brains has reported the aberrant expression of METTL3 and RBM15B in the AD hippocampus and indicated that the accumulation of METTL3 in the insoluble fractions positively correlated with that of Tau in hippocampal lysates, suggesting that potential perturbations in m6A signaling may contribute towards neuronal dysfunction in AD (Huang et al., 2020).