Stroke was found to significantly increase the global m6A methylation levels in mouse cortex after reperfusion of transient focal ischemia and the genome‐wide analysis of the methylated RNAs showed that 147 transcripts (127 mRNAs and 20 lncRNAs) have altered m6A levels, among which 95% (122 mRNAs and 17 lncRNAs) were significantly hypermethylated after stroke, which may due to the downregulation of FTO (Chokkalla et al., 2019). Here, FTO is linked to stroke disorder.