For example, in Sjögren syndrome which is dominated by Th1 reactions, serum IL-13 level is significantly increased in patients, and IL-13 is found to aggravate lacrimal gland destruction and dysfunction by promoting the production of interferon-γ as well as the recruitment of mast cells into the glands.5 However, till now, there is no report showing whether IL-13 contributed to cell senescence in Sjögren syndrome. Here, IL13 is linked to Sjogren syndrome.