TMEM63C and hereditary spastic paraplegia: Furthermore, the yeast TMEM16 orthologue, Ist2p, is a tether protein connecting theER and the plasma membrane, identifying a role of some TMEM16 family members at membranecontact sites.21,22 Here we present genetic, clinical and molecular datathat identify biallelic variants in TMEM63C probably leading to loss offunction, as a cause of both pure and complex HSP.