Interestingly, FTD-MND (the clinical form with the smallest hypothalamus) is typically characterised by TDP-43 pathology rather than tau (Tan et al., 2015), whilst MAPT (causing tau pathology) was more affected than C9orf72 and GRN, both presenting with TDP-43 accumulation at post-mortem. Here, C9orf72 is linked to frontotemporal dementia.