A post-mortem study in C9orf72 expansion carriers with symptoms in the ALS-FTD spectrum has found dipeptide repeat protein inclusions in the suprachiasmatic nucleus (part of the a-iHyp subunit and related to circadian sleep-wake regulation), but no TDP-43 deposition (Dedeene et al., 2019). Here, TARDBP is linked to frontotemporal dementia.