Interestingly, direct P53 targets associated with apoptosis, such as PIDD1, BAX, SIVA1, EI24, SHISA5, AIFM2, and IGFBP3, were downregulated (Figure S7, Supporting Information), suggesting that TMEM44‐AS1 may promote tumor chemoresistance by inhibiting the P53 signaling pathway. This evidence concerns the gene PIDD1 and neoplasm.