This is consistent with results from a small-scale study by Seckl, Campbell [42] assessing adrenal steroid hormone levels in seven patients compared to seven controls and most likely implies a chronic ACTH overdrive in MDD when also considering the observation of increased corticosterone levels in patients with Cushing’s disease and the (patho-)physiology of corticosterone synthesis [36]. This evidence concerns the gene POMC and major depressive disorder.