AIM2 and neoplasm: By contrast, expression levels of known tumor suppressors, such as EPB41L4A, SERPINB2, AIM2, NR4A3, and LUM, but also those with relevance in tumor cell invasion, extracellular matrix remodeling, thus promoting oncogenic properties (ICAM1, IL1RN, MMP1/3, DCN, HS3ST3B1, SEL1L3, STC1, and EEF1A2), were significantly increased (Fig. 7).