Established in 2007, the Transthyretin Amyloidosis Outcomes Survey (THAOS) is the largest ongoing, global, longitudinal observational study of patients with ATTR amyloidosis, including both inherited and wild-type disease, and asymptomatic carriers of pathogenic TTR mutations (NCT00628745) [8]. The gene discussed is TTR; the disease is Familial transthyretin-related amyloidosis.