There are two distinct forms of ATTR amyloidosis: hereditary or variant ATTR amyloidosis (ATTRv amyloidosis), which is caused by pathogenic mutations that destabilize the TTR protein, and wild-type ATTR amyloidosis (ATTRwt amyloidosis), which results from the accumulation of wild-type TTR protein [2, 3]. The gene discussed is TTR; the disease is amyloidosis.