Tumor angiogenesis occurs under the influence of fibroblast growth factor (FGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), placental growth factor (PLGF),tumor necrosis factor-alpha (TNFa), platelet-derived growth factor (PDGF) and angiogenin (Ang) [126, 127]. Here, TNF is linked to neoplasm.