DCLK1 and colonic neoplasm: While most of the literature reported the biological functions of DCLK1 related to inducing EMT, self-renewal, sphere forming, maintaining quiescence, initiating colon cancer, and resisting cell death in CRC cell lines (13, 15, 17, 40, 57), it is worth mentioning that the anti-DCLK1 antibodies generally utilized in these studies could detect sequence homology epitopes of both isoforms (anti-DCLK1 L/S); hence, the specific implication of each DCLK1 isoform requires further investigation.