LGR5 and cancer: As a consequence, finding of specific CSC biomarkers, including Leucine-rich repeat-containing G-proteine-coupled receptor 5 (Lgr5), Nanog, Oct 4, CD166, and Aldehyde dehydrogenase isoform 1 (ALDH1), may shed new light on targeted-therapy strategies and lead to prolonged survival of patients with cancer [5, 6].