Therefore, based on the importance of DCLK1 as a specific CRC CSC marker, this comprehensive systematic review and meta-analysis was aimed to assess the oncogenic isoform-specific functions of DCLK1-L and DCLK1-S in in-vitro and in-vivo evidence and to evaluate the prognostic significance of DCLK1 isoforms in colorectal cancer. This evidence concerns the gene DCLK1 and colorectal carcinoma.