When the investigations were stratified based on different DCLK1 isoforms, a poor OS was observed for three studies with DCLK1-L/S (HR = 3.701, 95% CI 2.029–6.752, p < 0.001) and one study with DCLK1-S (HR = 7.930, 95% CI 2.252–27.924, p = 0.001), while increased expression of DCLK1-L (n = 1) was closely associated with better OS in CRC patients (HR = 0.590, 95% CI 0.352–0.989, p = 0.045). The gene discussed is DCLK1; the disease is colorectal carcinoma.