In a retrospective cohort study that included 5947 Caucasian participants aged 28–75 years with no pre-existing diabetes, Kunutsor et al. found that baseline HDL-C levels were also negatively associated with DM through multivariate Cox proportional hazards model analysis(HR = 0.79, 95%CI: 0.68–0.92, P = 0.002) after adjusting age, sex, FPG, BMI, SBP, smoking status, alcohol consumption, parental history of diabetes, TG, estimated glomerular filtration rate, loge urinary albumin excretion, and loge homeostasis model assessment of insulin resistance, paraoxonase-1 [9]. The gene discussed is PON1; the disease is diabetes mellitus.