TNFRSF10A and arthritic joint disease: Finally, there was only slight, but statistically significant, evidence to support arthritis induction (arthritis inflammatory score, mean ± SD) in WT-CIA + ODE (0.31 ± 0.26; p = 0.032) and DR4-CIA + ODE (0.40 ± 0.22; p = 0.014) mice versus saline-treated (0.0 ± 0.0) animals (Additional file 3: Fig. S3B).