Following 4 weeks of ODE exposure, there was only slight evidence of arthritis (arthritis inflammatory score, mean ± SD) in WT-ODE (0.2 ± 0.27; p = 0.17) and DR4-ODE (0.3 ± 0.27; p = 0.049) versus WT-saline (0.0 ± 0.0) and DR4-saline (0.0 ± 0.0) control mice, respectively (Additional file 4: Fig. S4A). Here, TNFRSF10A is linked to arthritic joint disease.