NPPB and hydrops fetalis: In patients who also had available data for NT-proBNP at randomization and at week 48 (PARAGON-HF, n = 1489) or week 32 (PARADIGM-HF, n = 757), this difference remained significant after additional adjustment for change in NT-proBNP (− 0.17, 95% CI − 0.25 to − 0.09, P < 0.001).