INS and diabetes mellitus: In the subgroup of patients with diabetes who used either insulin or sulfonylurea or both at baseline (n = 2493) the risk was higher with sacubitril/valsartan (7.0% vs. 5.0%; HR 1.42 (95% CI 1.03–1.97, P = 0.034), whereas in patients with diabetes who used neither insulin nor sulfonylurea at baseline (n = 3680) no significantly increased risk was observed in the sacubitril/valsartan group (1.0% vs. 0.7%; HR 1.43, 95% CI 0.69–2.97, P = 0.34).