Patients with diabetes who experienced at least one hypoglycemic adverse event had significantly higher baseline HbA1c (7.67 ± 1.50% vs. 7.33 ± 1.46%, P = 0.042), were more likely to use insulin (62.2% vs. 26.2%, P < 0.001) or sulfonylureas (28.0% vs. 19.8%, P = 0.07) but the latter finding did not meet statistical significance. The gene discussed is INS; the disease is diabetes mellitus.