INS and diabetes mellitus: Among the patients with diabetes who did not use any antihyperglycemic medications at randomization, the proportion who initiated treatment with non-insulin antihyperglycemic medications was numerically lower in the sacubitril/valsartan group than in the control group (11.5% vs. 14.3%; HR 0.80, 95% CI 0.64–1.01, P = 0.06) and this was not significantly modified by LVEF (Pinteraction = 0.93; Fig. 3).