Among the 634 patients with diabetes who did not use any antihyperglycemic drugs at randomization, the proportions of patients who initiated treatment with non-insulin antihyperglycemic medications were similar between treatment groups (13.7% vs. 15.7%; HR: 0.88, 95% CI 0.58–1.32, P = 0.53). This evidence concerns the gene INS and diabetes mellitus.