In addition, RCAN1 was reduced in a HCC mouse model, by exposure to N-nitroso genotoxic hepatocarcinogens, diethylnitrosamine (DEN), and ethylnitrosourea (ENU) (Suenaga et al. 2013; Watanabe et al. 2009), and in a CCl4-induced liver fibrosis mouse model (Pan et al. 2019). The gene discussed is RCAN1; the disease is hepatocellular carcinoma.