Many studies have confirmed that RCAN1 can inhibit cancer cell proliferation and migration via inhibition of the CN-NFAT pathway and NFAT-regulated transcription of genes such as insulin-like growth factor 1 (IGF-1) (Jin et al. 2017), interferon alpha inducible protein 27 (IFI27) (Lao et al. 2021), C-X-C motif chemokine ligand 8 (CXCL8), interleukin-8 (IL-8), and interleukin-11 (IL-11) (Sales et al. 2009, 2010; Maldonado-Pérez et al. 2009). This evidence concerns the gene IGF1 and cancer.