PDILT and chronic kidney disease: The genetic effect sizes were also larger in the two subgroups when viewed relative to the phenotype variance (on the example of HUNT, Methods): rs77924615 variant (UMOD-PDILT locus) explained 0.38% of the eGFR-decline variance in DM, 0.47% in CKD, and 0.22% overall; the 9-variants jointly explained 1.14%, 1.48%, and 0.51%, respectively.