For example, the two genes showing the most divergent response to IFNγ in SZ and control NPCs (NDUFA2 and NDUFS3) were mitochondrial complex I genes, suggesting that schizophrenia donor cells are relatively driven to conserve energy in response to an infection, while healthy donor cells are able to expend more energy to restore health (Park et al., 2020). This evidence concerns the gene IFNG and infection.