In the context of patients treated with full-dose tPA, end-stage renal disease was associated with an increased incidence of pleural bleeding (7 of 79 patients [8.9%] vs 51 of 1,301 patients [3.9%]; P = .037; OR, 2.4; 95% CI, 1.04-5.43). This evidence concerns the gene PLAT and stage 5 chronic kidney disease.