CTLA4 and small cell lung carcinoma: Dual ICIs combination with the anti-PD1, durvalumab, and the anti-CTLA-4, tremelimumab, were investigated in combination with or without induction stereotactic body radiation therapy (SBRT) to one selected tumor site in 18 patients with relapsed or metastatic SCLC in a phase II study (NCT02701400) [28].